InteGO2

Introduction to InteGO2

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InteGO2 is an easy-to-use web interface which can be used to calculate and visualize the gene-to-gene functional similarities based on GO.

InteGO2 supplies eight state-of-art gene functional similarity measurements for users, including an integrative approach that automatically choose and weigh appropriate measurements for the input genes. Currently, 24 organisms are available. The GO annotations of all organisms are downloaded from the GO website and are updated automatically to ensure that the most recent annotations are used.

Note: The online version of InteGO2 can only compute similarities for no more than 2000 genes in one run. If you need to compute similarities of more genes, please download the local version of InteGO2 (python package) at here.

Citation: (1) Jiajie Peng, Hongxiang Li, Yongzhuang Liu, Liran Juan, Qinghua Jiang, Yadong Wang and Jin Chen. InteGO2:a web tool for measuring and visualizing gene semantic similarities using Gene Ontology. BMC Genomics.2016, 17:530. (2) Jiajie Peng, Yadong Wang, Jin Chen.Towards integrative gene functional similarity measurement. BMC Bioinformatics.2014, 15:1

Step 1: Input the gene list or gene pair list

Select the organism

Select the type of input set

gene list gene pair list

*Sample gene list for test*

Click here to fill sample gene in form. (The sample contains 30 genes for Homo sapiens(9606), the type of gene name is UniProtKB.)

Provide your list / pair list

OR upload your own file:

The input format is one gene per line or one gene pair per line split with space letter.

Select the type of gene name

Step 2: Select measurements and Gene Ontology categories

Select the similarity measurement

Select GO category

Molecular Function Biological Process Cellular Component

Step 3: Submission Information (Optional)

Your Email

Experiment Name